Cyclophosphamide Unmasks an Antimetastatic Effect of Local Tumor Cryoablation

Cryoablation of a solitary tumor mass releases intact tumor antigens and can induce protective antitumor immunity but has limited efficacy in the treatment of established metastatic cancer. Cyclophosphamide (Cy), an anticancer drug, selectively depletes regulatory T cells (T(reg)s) and attenuates su...

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Autori principali: Levy, Moshe Yair, Sidana, Abhinav, Chowdhury, Wasim H., Solomon, Steven B., Drake, Charles G., Rodriguez, Ronald, Fuchs, Ephraim J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Pharmacology and Experimental Therapeutics 2009
Soggetti:
Cellular and Molecular
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713091/
https://ncbi.nlm.nih.gov/pubmed/19407102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.152603
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