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Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation
Sandhoff disease is a lysosomal storage disorder characterized by the absence of β-hexosaminidase and storage of G(M2) ganglioside and related glycolipids in the central nervous system. The glycolipid storage causes severe neurodegeneration through a poorly understood pathogenic mechanism. In sympto...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC27130/ https://ncbi.nlm.nih.gov/pubmed/11005868 |
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