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A structural model for K(2P) potassium channels based on 23 pairs of interacting sites and continuum electrostatics

K(2P)Ø, the two-pore domain potassium background channel that determines cardiac rhythm in Drosophila melanogaster, and its homologues that establish excitable membrane activity in mammals are of unknown structure. K(2P) subunits have two pore domains flanked by transmembrane (TM) spans: TM1-P1-TM2-...

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Autors principals: Kollewe, Astrid, Lau, Albert Y., Sullivan, Ashley, Benoît Roux, Goldstein, Steve A.N.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712977/
https://ncbi.nlm.nih.gov/pubmed/19564427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200910235
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