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Jab1 Mediates Protein Degradation of Rad9/Rad1/Hus1 Checkpoint Complex
The Rad1-Rad9-Hus1 (9-1-1) complex serves a dual role as a DNA-damage sensor in checkpoint signaling and as a mediator in DNA repair pathway. However, the intercellular mechanisms that regulate 9-1-1 complex are poorly understood. Jab1, the fifth component of the COP9 signalosome complex, plays a ce...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2712929/ https://ncbi.nlm.nih.gov/pubmed/17583730 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.05.095 |
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