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Foxa2-dependent hepatic gene regulatory networks depend on physiological state

Bile acids are powerful detergents produced by the liver to aid in the absorption of dietary lipids. We recently reported a novel role for Foxa2 in bile acid metabolism. The winged helix transcription factor Foxa2 is required to prevent intrahepatic cholestasis and liver injury in mice fed a cholic...

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Autors principals: Bochkis, Irina M., Schug, Jonathan, Rubins, Nir E., Chopra, Atul R., O'Malley, Bert W., Kaestner, Klaus H.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712224/
https://ncbi.nlm.nih.gov/pubmed/19417011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.90376.2008
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