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Targeted Disruption of the BDNF Gene Perturbs Brain and Sensory Neuron Development but Not Motor Neuron Development

Brain-derived neurotrophic factor (BDNF), a neurotrophin, enhances the survival and differentiation of several classes of neurons in vitro. To determine its essential functions, we have mutated the BDNF gene. Most homoxygote mutants die within 2 days after birth, but a fraction live for 2–4 weeks. T...

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Autors principals: Jones, Kevin R., Fariñas, Isabel, Backus, Carey, Reichardt, Louis F.
Format: Artigo
Idioma:Inglês
Publicat: 1994
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711896/
https://ncbi.nlm.nih.gov/pubmed/8137432
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