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Lack of Neurotrophin-3 Results in Death of Spinal Sensory Neurons and Premature Differentiation of Their Precursors

To understand mechanisms resulting in the absence of two-thirds of spinal sensory neurons in mice lacking NT-3, we have compared dorsal root ganglia development in normal and mutant embryos. The reduction in neurons, achieved by E13, results from several deficits: first, elevated neuronal apoptosis...

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Bibliografski detalji
Glavni autori: Fariñas, Isabel, Yoshida, Cathleen K., Backus, Carey, Reichardt, Louis F.
Format: Artigo
Jezik:Inglês
Izdano: 1996
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758230/
https://ncbi.nlm.nih.gov/pubmed/8982156
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