Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1

Proper regulation of the cAMP-dependent protein kinase (protein kinase A, PKA) is necessary for cellular homeostasis, and dysregulation of this kinase is crucial in human disease. Mouse embryonic fibroblasts (MEFs) lacking the PKA regulatory subunit Prkar1a show altered cell morphology and enhanced...

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Bibliografske podrobnosti
Main Authors: Nadella, Kiran S, Saji, Motoyasu, Jacob, Naduparambil K, Pavel, Emilia, Ringel, Matthew D, Kirschner, Lawrence S
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
Teme:
Scientific Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711837/
https://ncbi.nlm.nih.gov/pubmed/19424295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.58
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