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Endothelin antagonism in portal hypertensive mice: implications for endothelin receptor-specific signaling in liver disease
Endothelin-1 (ET-1), a potent vasoactive peptide, plays an important role in the pathogenesis of liver disease and portal hypertension. Two major endothelin receptors (ET-A and ET-B) mediate biological effects, largely on the basis of their known downstream signaling pathways. We hypothesized that t...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Physiological Society
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711758/ https://ncbi.nlm.nih.gov/pubmed/19299580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.90405.2008 |
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