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IL-18 induction of osteopontin mediates cardiac fibrosis and diastolic dysfunction in mice
Osteopontin (OPN), a key component of the extracellular matrix, is associated with the fibrotic process during tissue remodeling. OPN and the cytokine interleukin (IL)-18 have been shown to be overexpressed in an array of human cardiac pathologies. In the present study, we determined the role of IL-...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711747/ https://ncbi.nlm.nih.gov/pubmed/19429811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01285.2008 |
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