Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity

Human cytochrome P-450 (CYP)2J2 is abundant in heart and active in biosynthesis of epoxyeicosatrienoic acids (EETs). Recently, we demonstrated that these eicosanoid products protect myocardium from ischemia-reperfusion injury. The present study utilized transgenic (Tr) mice with cardiomyocyte-specif...

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Detalhes bibliográficos
Main Authors: Zhang, Yunfang, El-Sikhry, Haitham, Chaudhary, Ketul R., Batchu, Sri Nagarjun, Shayeganpour, Anooshirvan, Jukar, Taibeh Orujy, Bradbury, J. Alyce, Graves, Joan P., DeGraff, Laura M., Myers, Page, Rouse, Douglas C., Foley, Julie, Nyska, Abraham, Zeldin, Darryl C., Seubert, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711738/
https://ncbi.nlm.nih.gov/pubmed/19429816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00983.2008
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