Targeted disruption of the voltage-dependent calcium channel α(2)/δ-1-subunit

Cardiac L-type voltage-dependent Ca(2+) channels are heteromultimeric polypeptide complexes of α(1)-, α(2)/δ-, and β-subunits. The α(2)/δ-1-subunit possesses a stereoselective, high-affinity binding site for gabapentin, widely used to treat epilepsy and postherpetic neuralgic pain as well as sleep d...

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Main Authors: Fuller-Bicer, Geraldine A., Varadi, Gyula, Koch, Sheryl E., Ishii, Masakazu, Bodi, Ilona, Kadeer, Nijiat, Muth, James N., Mikala, Gabor, Petrashevskaya, Natalia N., Jordan, Michael A., Zhang, Sui-Po, Qin, Ning, Flores, Christopher M., Isaacsohn, Idit, Varadi, Maria, Mori, Yasuo, Jones, W. Keith, Schwartz, Arnold
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711723/
https://ncbi.nlm.nih.gov/pubmed/19429829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00122.2009
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