Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats

Angiotensin-(1-12) [ANG-(1-12)] is a newly identified peptide detected in a variety of rat tissues, including the brain. To determine whether brain ANG-(1-12) participates in blood pressure regulation, we treated male adult (mRen2)27 hypertensive rats (24–28 wk of age) with Anti-ANG-(1-12) IgG or Pr...

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Main Authors: Isa, Katsunori, García-Espinosa, Maria Antonia, Arnold, Amy C., Pirro, Nancy T., Tommasi, Ellen N., Ganten, Detlev, Chappell, Mark C., Ferrario, Carlos M., Diz, Debra I.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2009
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711698/
https://ncbi.nlm.nih.gov/pubmed/19403863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.90588.2008
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