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VCAM-1 Signals Activate Endothelial Cell Protein Kinase Cα via Oxidation
Lymphocyte binding to VCAM-1 activates endothelial cell NADPH oxidase, resulting in the generation of 1 μM H(2)O(2). This is required for VCAM-1-dependent lymphocyte migration. In this study, we identified a role for protein kinase Cα (PKCα) in VCAM-1 signal transduction in human and mouse endotheli...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711556/ https://ncbi.nlm.nih.gov/pubmed/17056569 |
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