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Gene-Gene Cooperativity in Small Networks

We show how to construct a reduced description of interacting genes in noisy, small regulatory networks using coupled binary spin variables. Treating both the protein number and gene expression state variables stochastically and on equal footing, we propose a mapping that connects the molecular leve...

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Detalles Bibliográficos
Main Authors: Walczak, Aleksandra M., Wolynes, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711489/
https://ncbi.nlm.nih.gov/pubmed/19486675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.03.005
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