Quantitative Detection of Small Molecule/DNA Complexes Employing a Force-Based and Label-Free DNA-Microarray

Force-based ligand detection is a promising method to characterize molecular complexes label-free at physiological conditions. Because conventional implementations of this technique, e.g., based on atomic force microscopy or optical traps, are low-throughput and require extremely sensitive and sophi...

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Detalhes bibliográficos
Main Authors: Ho, Dominik, Dose, Christian, Albrecht, Christian H., Severin, Philip, Falter, Katja, Dervan, Peter B., Gaub, Hermann E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Nucleic Acid
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711479/
https://ncbi.nlm.nih.gov/pubmed/19486688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.02.059
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