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Conformational Change in MSH2-MSH6 upon Binding DNA Coupled to ATPase Activity
Postreplication DNA mismatch repair is initiated by the eukaryotic protein MSH2-MSH6 or the prokaryotic protein MutS, both showing overall conserved structure and functionality. Crystal structures of MSH2-MSH6 and MutS bound to the mismatch DNA reveal a closed architecture of the clamp and the lever...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711459/ https://ncbi.nlm.nih.gov/pubmed/19486659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.04.012 |
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