Single-Channel Current Through Nicotinic Receptor Produced by Closure of Binding Site C-Loop

We investigated the initial coupling of agonist binding to channel gating of the nicotinic acetylcholine receptor using targeted molecular-dynamics (TMD) simulation. After TMD simulation to accelerate closure of the C-loops at the agonist binding sites, the region of the pore that passes through the...

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Autors principals: Wang, Hai-Long, Toghraee, Reza, Papke, David, Cheng, Xiao-Lin, McCammon, J. Andrew, Ravaioli, Umberto, Sine, Steven M.
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2009
Matèries:
Biophysical Theory and Modeling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711404/
https://ncbi.nlm.nih.gov/pubmed/19413963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.02.020
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