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Polypeptide Point Modifications with Fatty Acid and Amphiphilic Block Copolymers for Enhanced Brain Delivery

There is a tremendous need to enhance delivery of therapeutic polypeptides to the brain to treat disorders of the central nervous system (CNS). The brain delivery of many polypeptides is severely restricted by the blood—brain barrier (BBB). The present study demonstrates that point modifications of...

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Detalhes bibliográficos
Main Authors: Batrakova, Elena V., Vinogradov, Serguei V., Robinson, Sandra M., Niehoff, Michael L., Banks, William A., Kabanov, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711208/
https://ncbi.nlm.nih.gov/pubmed/16029020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc049730c
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