MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

MDM4 is a key regulator of p53, whose biological activities depend on both transcriptional activity and transcription-independent mitochondrial functions. MDM4 binds to p53 and blocks its transcriptional activity; however, the main cytoplasmic localization of MDM4 might also imply a regulation of p5...

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Bibliografiska uppgifter
Huvudupphovsmän: Mancini, Francesca, Di Conza, Giusy, Pellegrino, Marsha, Rinaldo, Cinzia, Prodosmo, Andrea, Giglio, Simona, D'Agnano, Igea, Florenzano, Fulvio, Felicioni, Lara, Buttitta, Fiamma, Marchetti, Antonio, Sacchi, Ada, Pontecorvi, Alfredo, Soddu, Silvia, Moretti, Fabiola
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711189/
https://ncbi.nlm.nih.gov/pubmed/19521340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.154
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