How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic

The 39-kDa Escherichia coli enzyme MccB catalyses a remarkable posttranslational modification of the MccA heptapeptide during the biosynthesis of microcin C7 (MccC7), a ‘Trojan horse' antibiotic. The approximately 260-residue C-terminal region of MccB is homologous to ubiquitin-like protein (UB...

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Main Authors: Regni, Catherine A, Roush, Rebecca F, Miller, Darcie J, Nourse, Amanda, Walsh, Christopher T, Schulman, Brenda A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711183/
https://ncbi.nlm.nih.gov/pubmed/19494832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.146
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