Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms

Chromosomal abnormalities are frequent in myeloid malignancies, but in most cases of myelodysplasia (MDS) and myeloproliferative neoplasms (MPN), underlying pathogenic molecular lesions are unknown. We identified recurrent areas of somatic copy number–neutral loss of heterozygosity (LOH) and deletio...

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Detalhes bibliográficos
Main Authors: Jankowska, Anna M., Szpurka, Hadrian, Tiu, Ramon V., Makishima, Hideki, Afable, Manuel, Huh, Jungwon, O'Keefe, Christine L., Ganetzky, Rebecca, McDevitt, Michael A., Maciejewski, Jaroslaw P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710933/
https://ncbi.nlm.nih.gov/pubmed/19372255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-205690
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