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Bacillus anthracis o-succinylbenzoyl-CoA synthetase: reaction kinetics and a novel inhibitor mimicking its reaction intermediate

O-succinylbenzoyl-CoA (OSB-CoA) synthetase (EC 6.2.1.26) catalyzes the ATP-dependent condensation of o-succinylbenzoate (OSB) and CoA to form OSB-CoA, the fourth step of the menaquinone biosynthetic pathway in Bacillus anthracis. Gene knockout studies have highlighted this enzyme as a potential targ...

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書目詳細資料
Main Authors: Tian, Yang, Suk, Dae-Hwan, Cai, Feng, Crich, David, Mesecar, Andrew D.
格式: Artigo
語言:Inglês
出版: 2008
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710618/
https://ncbi.nlm.nih.gov/pubmed/18973344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801311d
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