Use of a Novel Genetic Mouse Model to Investigate the Role of Folate in Colitis-Associated Colon Cancer

Inflammatory bowel disease (IBD) patients are at high risk for developing folate deficiency and colon cancer. Since it is difficult to study the subtle global and gene-specific epigenetic mechanisms involved in folate-mediated tumor initiation and promotion, we have generated genetically modified mo...

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Detalhes bibliográficos
Main Authors: Chapkin, Robert S., Kamen, Barton A., Callaway, Evelyn S., Davidson, Laurie A., George, Nysia I., Wang, Naisyin, Lupton, Joanne R., Finnell, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710403/
https://ncbi.nlm.nih.gov/pubmed/18926688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jnutbio.2008.07.001
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