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Monitoring of an RNA Multistep Folding Pathway by Isothermal Titration Calorimetry

Isothermal titration calorimetry was used to monitor the energetic landscape of a catalytic RNA, specifically that of the hepatitis delta virus ribozyme. Using mutants that isolated various tertiary interactions, the thermodynamic parameters of several ribozyme-substrate intermediates were determine...

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Autors principals: Reymond, Cédric, Bisaillon, Martin, Perreault, Jean-Pierre
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710038/
https://ncbi.nlm.nih.gov/pubmed/19134473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.09.033
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