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Accuracy of genome-wide imputation of untyped markers and impacts on statistical power for association studies

BACKGROUND: Although high-throughput genotyping arrays have made whole-genome association studies (WGAS) feasible, only a small proportion of SNPs in the human genome are actually surveyed in such studies. In addition, various SNP arrays assay different sets of SNPs, which leads to challenges in com...

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Detalhes bibliográficos
Main Authors: Hao, Ke, Chudin, Eugene, McElwee, Joshua, Schadt, Eric E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709633/
https://ncbi.nlm.nih.gov/pubmed/19531258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-10-27
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