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Loss of Cardiolipin Leads to Longevity Defects That Are Alleviated by Alterations in Stress Response Signaling

Perturbation of cardiolipin (CL) synthesis in yeast cells leads to defective respiratory chain function and mitochondrial DNA loss, both of which have been implicated in aging in mammals. The availability of yeast CL mutants enabled us to directly investigate the role of CL synthesis in aging. In th...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhou, Jingming, Zhong, Quan, Li, Guiling, Greenberg, Miriam L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709391/
https://ncbi.nlm.nih.gov/pubmed/19401462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.003236
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