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Differential Inhibitor of Gβγ Signaling to AKT and ERK Derived from Phosducin-like Protein: EFFECT ON SPHINGOSINE 1-PHOSPHATE-INDUCED ENDOTHELIAL CELL MIGRATION AND IN VITRO ANGIOGENESIS

Differential inhibitors of Gβγ-effector regions are required to dissect the biological contribution of specific Gβγ-initiated signaling pathways. Here, we characterize PhLP-M1-G149, a Gβγ-interacting construct derived from phosducin-like protein 1 (PhLP) as a differential inhibitor of Gβγ, which, in...

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Main Authors: Guzmán-Hernández, María Luisa, Vázquez-Macías, Aleida, Carretero-Ortega, Jorge, Hernández-García, Ricardo, García-Regalado, Alejandro, Hernández-Negrete, Ivette, Reyes-Cruz, Guadalupe, Gutkind, J. Silvio, Vázquez-Prado, José
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709366/
https://ncbi.nlm.nih.gov/pubmed/19403526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008839
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