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The Chemical Properties of Oxopropenyl Adducts of Purine and Pyrimidine Nucleosides and Their Reactivity toward Amino Acid Crosslink Formation

N(2)-Oxopropenyldeoxyguanosine (2) forms in duplex DNA by modification of dG residues with base propenal or malondialdehyde. The pK(a) of 2 was estimated to be 6.9 from the pH dependence of its ring-closing to the pyrimidopurinone derivative 1. The acidity of 2 may be an important determinant of its...

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Autori principali: Szekely, Joseph, Rizzo, Carmelo J., Marnett, Lawrence J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708936/
https://ncbi.nlm.nih.gov/pubmed/18225895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja074506u
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