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Dysregulation of Human β-Defensin-2 Protein in Inflammatory Bowel Disease

BACKGROUND: Human β-defensin-2 (HBD2) is an antimicrobial peptide implicated in the pathogenesis of inflammatory bowel disease (IBD). Low copy number and concomitant low mRNA expression of the HBD2 gene have been implicated in susceptibility to colonic Crohn's Disease (CD). We investigated the...

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Detalhes bibliográficos
Main Authors: Aldhous, Marian C., Noble, Colin L., Satsangi, Jack
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708916/
https://ncbi.nlm.nih.gov/pubmed/19617917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006285
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