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CRM1-mediated Nuclear Export of Dengue Virus RNA Polymerase NS5 Modulates Interleukin-8 Induction and Virus Production

Although all established functions of dengue virus NS5 (nonstructural protein 5) occur in the cytoplasm, its nuclear localization, mediated by dual nuclear localization sequences, is essential for virus replication. Here, we have determined the mechanism by which NS5 can localize in the cytoplasm to...

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Detalhes bibliográficos
Main Authors: Rawlinson, Stephen M., Pryor, Melinda J., Wright, Peter J., Jans, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708855/
https://ncbi.nlm.nih.gov/pubmed/19297323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808271200
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