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Extracellular thiol-assisted selenium uptake dependent on the x(c)(−) cystine transporter explains the cancer-specific cytotoxicity of selenite
The selenium salt selenite (SeO(3)(2−)) is cytotoxic in low to moderate concentrations, with a remarkable specificity for cancer cells resistant to conventional chemotherapy. Our data show that selenium uptake and accumulation, rather than intracellular events, are crucial to the specific selenite c...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708693/ https://ncbi.nlm.nih.gov/pubmed/19549867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902204106 |
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