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Extracellular thiol-assisted selenium uptake dependent on the x(c)(−) cystine transporter explains the cancer-specific cytotoxicity of selenite

The selenium salt selenite (SeO(3)(2−)) is cytotoxic in low to moderate concentrations, with a remarkable specificity for cancer cells resistant to conventional chemotherapy. Our data show that selenium uptake and accumulation, rather than intracellular events, are crucial to the specific selenite c...

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Detalhes bibliográficos
Main Authors: Olm, Eric, Fernandes, Aristi P., Hebert, Christina, Rundlöf, Anna-Klara, Larsen, Erik H., Danielsson, Olof, Björnstedt, Mikael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708693/
https://ncbi.nlm.nih.gov/pubmed/19549867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902204106
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