mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

Peutz-Jeghers syndrome (PJS) is a familial cancer disorder due to inherited loss of function mutations in the LKB1/ STK11 serine/threonine kinase. PJS patients develop gastrointestinal hamartomas with 100% penetrance often in the second decade of life, and demonstrate an increased predisposition tow...

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Bibliographic Details
Main Authors: Shackelford, David B., Vasquez, Debbie S., Corbeil, Jacqueline, Wu, Shulin, Leblanc, Mathias, Wu, Chin-Lee, Vera, David R., Shaw, Reuben J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708689/
https://ncbi.nlm.nih.gov/pubmed/19541609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900465106
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