Mutagenesis of Varicella-Zoster Virus Glycoprotein B: Putative Fusion Loop Residues Are Essential for Viral Replication, and the Furin Cleavage Motif Contributes to Pathogenesis in Skin Tissue In Vivo

Glycoprotein B (gB), the most conserved protein in the family Herpesviridae, is essential for the fusion of viral and cellular membranes. Information about varicella-zoster virus (VZV) gB is limited, but homology modeling showed that the structure of VZV gB was similar to that of herpes simplex viru...

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Bibliographic Details
Main Authors: Oliver, Stefan L., Sommer, Marvin, Zerboni, Leigh, Rajamani, Jaya, Grose, Charles, Arvin, Ann M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708640/
https://ncbi.nlm.nih.gov/pubmed/19474103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00400-09
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