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Inactivation of contraceptive steroid hormones by human intestinal clostridia.

Steroid hormones reduced in ring-A are devoid of hormonal activity. In metabolic experiments we found that human fecal flora reduced the delta 4-3-keto structure of natural progestins to 3 alpha-hydroxy, 5 beta-steroid metabolites (3 alpha,5 beta) and of synthetic progestins to a mixture of 3 alpha,...

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Détails bibliographiques
Publié dans:J Clin Microbiol
Auteurs principaux: Bokkenheuser, V D, Winter, J, Cohen, B I, O'Rourke, S, Mosbach, E H
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 1983
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC270842/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6630441/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jcm.18.3.500-504.1983
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