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Evaluating the potential for halogen bonding in ketosteroid isomerase’s oxyanion hole using unnatural amino acid mutagenesis

There has recently been an increasing interest in controlling macromolecular conformations and interactions through halogen bonding. Halogen bonds are favorable electrostatic interactions between polarized, electropositive chlorine, bromine or iodine atoms and electronegative atoms such as oxygen or...

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Autors principals: Kraut, Daniel A, Churchil, Michael J, Dawson, Phillip E, Herschlag, Daniel
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708088/
https://ncbi.nlm.nih.gov/pubmed/19260691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb900016q
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