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Design of a heterotetrameric coiled coil

We have successfully designed a simple peptide sequence that forms highly stable coiled-coil heterotetramers. Our model system is based on the GCN4-pLI parallel coiled-coil tetramer, first described by Kim and coworkers (Harbury et al., Science 1993;262:1401–1407). We introduced glutamates at all of...

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Detalhes bibliográficos
Main Authors: Root, Benjamin C, Pellegrino, Laurel D, Crawford, Emily D, Kokona, Bashkim, Fairman, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708066/
https://ncbi.nlm.nih.gov/pubmed/19177574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.30
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