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A nonessential role for Arg 55 in cyclophilin18 for catalysis of proline isomerization during protein folding
The protein folding process is often in vitro rate-limited by slow cis-trans proline isomerization steps. Importantly, the rate of this process in vivo is accelerated by prolyl isomerases (PPIases). The archetypal PPIase is the human cyclophilin 18 (Cyp18 or CypA), and Arg 55 has been demonstrated t...
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| Huvudupphovsmän: | , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708058/ https://ncbi.nlm.nih.gov/pubmed/19185003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.28 |
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