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Discovery of amyloid-beta aggregation inhibitors using an engineered assay for intracellular protein folding and solubility
Genetic and biochemical studies suggest that Alzheimer's disease (AD) is caused by a series of events initiated by the production and subsequent aggregation of the Alzheimer's amyloid β peptide (Aβ), the so-called amyloid cascade hypothesis. Thus, a logical approach to treating AD is the d...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708054/ https://ncbi.nlm.nih.gov/pubmed/19177561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.33 |
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