Directed Differentiation of Dopaminergic Neuronal Subtypes from Human Embryonic Stem Cells

How dopamine (DA) neuronal subtypes are specified remains unknown. In this study we show a robust generation of functional DA neurons from human embryonic stem cells (hESCs) through a specific sequence of application of fibroblast growth factor 8 (FGF8) and sonic hedgehog (SHH). Treatment of hESC-de...

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Main Authors: Yan, Yiping, Yang, Dali, Zarnowska, Ewa D., Du, Zhongwei, Werbel, Brian, Valliere, Chuck, Pearce, Robert A., Thomson, James A., Zhang, Su-Chun
Format: Artigo
Jezik:Inglês
Izdano: 2005
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707939/
https://ncbi.nlm.nih.gov/pubmed/15917474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/stemcells.2004-0365
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