Protease Activated Receptor Signaling Is Required for African Trypanosome Traversal of Human Brain Microvascular Endothelial Cells

BACKGROUND: Using human brain microvascular endothelial cells (HBMECs) as an in vitro model for how African trypanosomes cross the human blood-brain barrier (BBB) we recently reported that the parasites cross the BBB by generating calcium activation signals in HBMECs through the activity of parasite...

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Autors principals: Grab, Dennis J., Garcia-Garcia, Jose C., Nikolskaia, Olga V., Kim, Yuri V., Brown, Amanda, Pardo, Carlos A., Zhang, Yongqing, Becker, Kevin G., Wilson, Brenda A., de A. Lima, Ana Paula C., Scharfstein, Julio, Dumler, J. Stephen
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707606/
https://ncbi.nlm.nih.gov/pubmed/19621073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0000479
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