Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

BACKGROUND AND AIMS: Pancreatic cancer is among the most dismal of human malignancies. Current therapeutic strategies are virtually ineffective in controlling advanced, metastatic disease. Recent evidence suggests that the Hedgehog signalling pathway is aberrantly reactivated in the majority of panc...

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Detalhes bibliográficos
Main Authors: Feldmann, G, Habbe, N, Dhara, S, Bisht, S, Alvarez, H, Fendrich, V, Beaty, R, Mullendore, M, Karikari, C, Bardeesy, N, Ouellette, M M, Yu, W, Maitra, A
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2707354/
https://ncbi.nlm.nih.gov/pubmed/18515410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2007.148189
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