Dissecting Structural and Functional Diversity of the Lantibiotic Mersacidin

Mersacidin is a tetracyclic lantibiotic with antibacterial activity against Gram-positive pathogens. To probe the specificity of the biosynthetic pathway of mersacidin and obtain analogs with improved antibacterial activity, an efficient system for generating variants of this lantibiotic was develop...

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Detalhes bibliográficos
Main Authors: Appleyard, Antony N., Choi, Shaila, Read, Daniel M., Lightfoot, Ann, Boakes, Steven, Hoffmann, Anja, Chopra, Ian, Bierbaum, Gabriele, Rudd, Brian A.M., Dawson, Michael J., Cortes, Jesus
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706954/
https://ncbi.nlm.nih.gov/pubmed/19477413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.03.011
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