Microcephalin regulates BRCA2 and Rad51-associated DNA double strand break repair

Microcephalin (MCPH1) is a BRCT-domain containing protein involved in the cellular response to DNA damage that has been implicated in autosomal recessive primary microcephaly. MCPH1 is recruited to sites of DNA double strand breaks by phosphorylated histone H2AX (γH2AX) but the mechanism by which MC...

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Huvudupphovsmän: Wu, Xianglin, Mondal, Gourish, Wang, Xianshu, Wu, Jianmin, Yang, Lin, Pankratz, Vernon S., Rowley, Matthew, Couch, Fergus J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706938/
https://ncbi.nlm.nih.gov/pubmed/19549900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4834
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