Cannabinoid CB(2) receptor agonists protect the striatum against malonate toxicity: relevance for Huntington’s disease

Cannabinoid agonists might serve as neuroprotective agents in neurodegenerative disorders. Here, we examined this hypothesis in a rat model of Huntington’s disease (HD) generated by intrastriatal injection of the mitochondrial complex II inhibitor malonate. Our results showed that only compounds abl...

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Détails bibliographiques
Auteurs principaux: Sagredo, Onintza, González, Sara, Aroyo, Ilia, Pazos, María Ruth, Benito, Cristina, Lastres-Becker, Isabel, Romero, Juan P., Tolón, Rosa M., Mechoulam, Raphael, Brouillet, Emmanuel, Romero, Julián, Fernández-Ruiz, Javier
Format: Artigo
Langue:Inglês
Publié: 2009
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706932/
https://ncbi.nlm.nih.gov/pubmed/19115380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.20838
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