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Mutational Separation of Aminoacylation and Cytokine Activities of Human Tyrosyl-tRNA Synthetase
Aminoacyl-tRNA synthetases are known for catalysis of aminoacylation. Significantly, some mammalian synthetases developed cytokine functions possibly linked to disease-causing mutations in tRNA synthetases. Not understood is how epitopes for cytokine signaling were introduced into catalytic scaffold...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2706086/ https://ncbi.nlm.nih.gov/pubmed/19477417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.03.006 |
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