Spectrum of mitochondrial DNA deletions within the Common Deletion region induced by low levels of UVB irradiation of human keratinocytes in vitro

We show that a single low-dose exposure of human epidermal keratinocytes (NHEK) to an FS20 light source in vitro can induce the formation of mitochondrial DNA deletions in a PCR detection assay. We used primer sets specifically designed to exclude amplification of segments containing the common dele...

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Hlavní autoři: Hwang, Bor-Jang, Kuttamperoor, Francis, Wu, Julia, Steinberg, Mark L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2706008/
https://ncbi.nlm.nih.gov/pubmed/19345726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2009.03.019
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