Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34(+) cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27(Kip), which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity

β(1)-integrin engagement on normal (NL) CD34(+) cells increases levels of the cyclin-dependent kinase inhibitor (cdki), p27(Kip), decreases cdk2 activity, and inhibits G(1)/S-phase progression. In contrast, β(1)-integrin engagement on chronic myelogenous leukemia (CML) CD34(+) cells does not inhibit...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Jiang, Yuehua, Zhao, Robert C. H., Verfaillie, Catherine M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10973491/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190104497
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