Abnormal integrin-mediated regulation of chronic myelogenous leukemia CD34(+) cell proliferation: BCR/ABL up-regulates the cyclin-dependent kinase inhibitor, p27(Kip), which is relocated to the cell cytoplasm and incapable of regulating cdk2 activity
β(1)-integrin engagement on normal (NL) CD34(+) cells increases levels of the cyclin-dependent kinase inhibitor (cdki), p27(Kip), decreases cdk2 activity, and inhibits G(1)/S-phase progression. In contrast, β(1)-integrin engagement on chronic myelogenous leukemia (CML) CD34(+) cells does not inhibit...
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| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2000
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27060/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10973491/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.190104497 |
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